![]() ![]() Finally, regarding 3' UTR binding, hnRNP L binding preferentially overlaps with predicted microRNA target sites, indicating global competition between hnRNP L and microRNA binding. These findings shed light on the longstanding question of differential hnRNP L-mediated splicing regulation. Additionally, position-dependent splicing regulation by hnRNP L was demonstrated: The protein represses splicing when bound to intronic regions upstream of alternative exons, and in contrast, activates splicing when bound to the downstream intron. Genome-wide mapping of hnRNP L binding revealed that the protein preferably binds to introns and 3' UTR. Sequence analysis of the iCLIP crosslink sites showed significant enrichment of C/A motifs, which perfectly agrees with the in vitro binding consensus obtained earlier by a SELEX approach, indicating that in vivo hnRNP L binding targets are mainly determined by the RNA-binding activity of the protein. To analyze activities of hnRNP L on a genome-wide level, we performed individual-nucleotide resolution crosslinking-immunoprecipitation in combination with deep-sequencing (iCLIP-Seq). Interestingly, hnRNP L can both activate and repress splicing of alternative exons, but the precise mechanism of hnRNP L-mediated splicing regulation remained unclear. We have previously characterized hnRNP L as a global regulator of alternative splicing, binding to CA-repeat, and CA-rich RNA elements. Please shoot us a line at and we will get back to you as quickly as possible.Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability. Additionally, it could be practical to have an I-CLIP for work and another one for personal use or two I-CLIP when you travel internationally. The I-CLIP comes in many different colors and leather types to always match your outfit. Many regular wallets do not fit in a stylish clutch bag - while the I-CLIP actually does.įor the same reason that you have many different shoes. Neither men nor women like bulging pockets or carry more weight than necessary. ![]() That said, we still offer an 'RFID shield' for the customer who needs 1000% piece of mind - we just don't try to sell you something you don't really need.Īll of our wallets are 100% made in Germany in own facilities in Bad Dürkheim (45min west of Heidelberg). You can find a good article on NPR that summarizes why you should not worry about this topic HERE. for pickpocketing which is a much higher risk. The best protection is to carry a slim wallet in your front pocket, esp. Only a fraction of cards in the US are actually RFID enabled and a potential thief would have to hold a large card reader in your crotch or close to your butt for an extended period of time (which we hope you'll notice). It was essentially invented by the wallet industry to charge more money for putting some aluminum foil in their wallets. No, our wallets don't come with 'native' RFID protection, because RFID theft is actually not a thing. Just throw your change in your pocket, leave it in the car or put it in your piggy bank when you come home.ĭo your wallets come with RFID protection? It also works perfectly in summer outfits known for their more delicate fabrics (linen, cotton, silk, etc.).ĭoes the I-CLIP have a place to store coins? I-CLIP is designed for small pockets (shirts, front pockets of your pants, jackets, etc.), which is the reason for the smooth, rounded edges and the fact that our money clip is covered and not external on the wallet. Check out this video we put together for you:ĭoes I-CLIP damage the liner of my pockets? However, there is a simple way to fold your bills and optimize the use of your I-CLIP. You can fold your bills in many different ways. Thanks to our patented design your cards are safely held in place even if you only carry your driver's license and/or a credit card. Which is an absolute record considering the extremely compact dimensions of our wallets.ĭo the cards slide out if I only use 1-2 cards? Plus we stand behind our product and have a hassle free return and warranty policy in case you experience any issues with your wallet. The material is also much gentler on the cards and bills compared to metal. Unlike a metal clip, our integrated money clip will retain its tension and flexibility. ![]() Not only is it super durable, but it’s also extremely lightweight and very comfortable to carry because of the flexible and rounded corners. We tested hundreds of different plastic composites and eventually developed our own high-performance formula (Robutense) and manufacturing process. Plastic is just the best material for our design. Why are the I-CLIP frames made of a plastic composite material? ![]()
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